Author: Gary Jackson

The Ultimate Guide to Microdosing Psychedelics

If you notice you’re having a hard time sleeping on the days you take the dose, you may need to adjust and take the dose even earlier. Keep in mind, most psychedelics wear off after about 6 hours, so you’ll want to time the dose so it gives you the desired benefits when you have the most to gain from it. In most cases, a microdose is around 10% of the standard psychoactive dose — or less.

  • Microdosing usually refers to the practice of taking tiny portions of psychedelic substances.
  • It’s relatively easy to take low-dose mescaline in the form of raw psychoactive cacti.
  • “Ketamine is exceedingly volatile and powerful,” said Giordano, who cautions against microdosing ketamine partly because it’s difficult to dose properly.
  • As a psychedelic guide, I am often asked about the long-term effects of microdosing mushrooms on mental health.
  • A handful of folks also reported microdosing out of curiosity and for fun.
  • For example, psilocybin is known to stimulate serotonin receptors in the brain, leading to increased levels of this chemical messenger which plays a key role in regulating mood and emotions.

Many microdosers prefer to use a scale when measuring their microdose since dosages can vary depending on the potency of your particular batch of mushrooms. In fact, recent studies published on NCBI have shown that some individuals may even experience benefits from a placebo effect when microdosing. The biggest risk to using psychedelics, by far, is accidentally macrodosing (taking a psychoactive dose). This is why it’s important to take the time to understand the correct dose of any substance you’re using and start with a dose that’s much lower than you think you need for the very first session. However, there are several high-level studies in the works as we speak exploring the short and long-term benefits of microdosing psychedelics.

How to Microdose Drugs Based on What You’re Using

However, due to the higher level of risk, microdosing MDMA isn’t recommended. If you’re still interested in microdoses of MDMA anyway, it’s important to limit the number of times you take it to just two or three doses per week, and stop after 3 or 4 weeks with a long rest period in between. When combined with goal-setting and intention, the effects of a microdose become stronger over long periods of time. It’s best to look at the improvements of microdosing as a long-term, gradual gain. It takes at least 2 weeks to develop new habits, and it can be even longer before you’re able to get into productive flow states on command.

  • We don’t have enough data yet to definitively say whether low dose, repetitive MDMA can lead to heart valve disease or not.
  • At that level, taken several times a week, some claim the drugs improve their mood, boost their creativity and give the world a brighter, shinier quality, like it’s in high-definition.
  • When using any psychedelic substance outside of a clinical setting, it is possible that the substance could be cut with other potentially lethal contaminants.
  • With that said, there are some theoretical issues with taking even small doses of certain compounds over long periods of time — such as MDMA.

It is the pioneering spirit, the first footfall on a new path, with future research holding the promise of new discoveries. Let us not forget our participants, those brave sailors venturing into the uncharted waters of microdosing, facing the binocular rivalry of two realities, enduring the attentional blink of perception. They come with motives, conditions, perhaps even a dash of mental illness. It’s a psychedelic dance, alright, but it’s a dance of healing, of enhancing learning, of creating new connections, much like the beautiful chaos of a New York rush hour. That’s why we doubled down with a blinded group, checking and cross-checking, no stone unturned, no mushroom unexamined, thanks to chemical analysis.

What Is Microdosing Mushrooms?

It’s crucial to find the right active dose for your mental health and stick to it, as a recent study has shown that consistent microdosing can have positive effects on mood and anxiety levels. When microdosing with psilocybin mushrooms, the length of time that effects last can vary depending on various factors such as individual tolerance and metabolism. However, according to a study published in Pubmed, microdosers reported effects lasting between 4-8 hours, which were significantly different from the placebo group. At the moment, the clinical research on microdosing mushrooms and other psychedelics is severely lacking.

how long does a microdose last

Ibogaine is a psychoactive indole alkaloid produced in a variety of African plant species — most notably Tabernanthe iboga. Some people choose to use a different isomer of THC that naturally has a lower tendency towards anxious side effects instead called delta 8 THC. With that said, it’s important to take some breaks from microdosing as well. Starting a micro-dosing regimen is an excellent time to dial in your ideal habits and routines. It’s also a great way to develop and solidify new habits and routines in your life.


However, microdosers who practice microdosing psychedelics with serotonergic psychedelics have reported experiencing subtle yet positive effects on their mood and creativity. Even though mushrooms are relatively safe, said Lowe, “The risks are more psychological than physiological. Individuals can experience negative emotions or emotions that are too intense. They can experience anxiety or increases in neuroticism.” By starting with as little as possible, a user can monitor for any difficult emotions then take even less next time. It’s also a good idea to avoid doing anything potentially dangerous like driving, said Hailey Shafir, a licensed clinical addiction specialist and mental health counselor.